John Nemunaitis Selected Research

talabostat

7/2009	Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma.
10/2006	Phase I trial of PT-100 (PT-100), a cytokine-inducing small molecule, following chemotherapy for solid tumor malignancy.

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John Nemunaitis Research Topics

Disease

117	Neoplasms (Cancer) 04/2022 - 02/2002
15	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019 - 08/2003
13	Ovarian Neoplasms (Ovarian Cancer) 01/2022 - 01/2005
13	Melanoma (Melanoma, Malignant) 09/2019 - 01/2005
7	Neoplasm Metastasis (Metastasis) 10/2021 - 04/2005
7	Adenocarcinoma 11/2020 - 02/2011
7	Prostatic Neoplasms (Prostate Cancer) 01/2019 - 04/2002
7	Thrombocytopenia (Thrombopenia) 01/2019 - 01/2004
7	Pancreatic Neoplasms (Pancreatic Cancer) 01/2018 - 03/2008
6	Fatigue 01/2021 - 10/2006
6	Ewing Sarcoma (Sarcoma, Ewing) 01/2019 - 01/2012
6	Lymphoma (Lymphomas) 01/2019 - 11/2015
6	Neutropenia 01/2018 - 04/2002
5	Carcinoma (Carcinomatosis) 03/2022 - 01/2005
5	Carcinogenesis 02/2021 - 06/2012
5	Hematologic Neoplasms (Hematological Malignancy) 12/2020 - 11/2003
5	Nausea 01/2019 - 10/2006
4	Squamous Cell Carcinoma of Head and Neck 03/2022 - 03/2002
4	Diarrhea 11/2020 - 01/2005
4	Fever (Fevers) 11/2020 - 05/2003
4	Multiple Myeloma 01/2019 - 01/2009
4	Disease Progression 02/2014 - 11/2003
3	Breast Neoplasms (Breast Cancer) 04/2022 - 02/2014
3	Colorectal Neoplasms (Colorectal Cancer) 10/2021 - 11/2011
3	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2019 - 01/2009
3	Vomiting 01/2019 - 10/2006
3	Insulinoma 01/2018 - 01/2012
3	Herpes Simplex 01/2018 - 11/2002
3	Lung Neoplasms (Lung Cancer) 11/2015 - 06/2006
2	Hyperglycemia 01/2019 - 09/2017
2	Anemia 01/2019 - 01/2019
2	Hypertension (High Blood Pressure) 01/2016 - 11/2015
2	Nonaka type Distal myopathy 11/2011 - 05/2010
2	Hypotension (Low Blood Pressure) 11/2011 - 10/2006
2	Li-Fraumeni Syndrome 12/2008 - 05/2007

Drug/Important Bio-Agent (IBA)

13	Small Interfering RNA (siRNA)IBA 01/2022 - 04/2005
13	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 10/2021 - 11/2003
12	VaccinesIBA 01/2022 - 11/2003
11	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 02/2002
11	Pharmaceutical PreparationsIBA 12/2020 - 01/2013
10	Biomarkers (Surrogate Marker)IBA 01/2022 - 05/2007
8	FANG vaccineIBA 12/2021 - 03/2012
7	Proteins (Proteins, Gene)FDA Link 03/2019 - 12/2004
7	Biological ProductsIBA 11/2015 - 02/2004
6	Carboplatin (JM8)FDA LinkGeneric 12/2020 - 01/2004
6	AntigensIBA 09/2019 - 02/2005
4	Paclitaxel (Taxol)FDA LinkGeneric 12/2020 - 01/2004
4	Phosphotransferases (Kinase)IBA 01/2020 - 07/2014
4	ixazomibIBA 01/2018 - 01/2016
3	FurinIBA 01/2022 - 03/2012
3	PlatinumIBA 01/2020 - 03/2012
3	talimogene laherparepvecIBA 09/2019 - 01/2016
3	MLN 8237IBA 01/2019 - 01/2018
3	Aurora Kinase AIBA 01/2019 - 01/2018
3	Antineoplastic Agents (Antineoplastics)IBA 01/2019 - 01/2009
3	ErbB Receptors (EGF Receptor)IBA 11/2018 - 03/2002
3	Insulin (Novolin)FDA Link 01/2018 - 02/2011
3	Proteasome InhibitorsIBA 01/2018 - 10/2016
3	Cytochrome P-450 CYP3AIBA 01/2018 - 01/2009
3	EnzymesIBA 01/2016 - 01/2009
3	RNA (Ribonucleic Acid)IBA 01/2016 - 01/2005
3	Transcription Factors (Transcription Factor)IBA 01/2014 - 02/2011
3	Prostate-Specific Antigen (Semenogelase)IBA 11/2008 - 04/2002
3	Hormones (Hormone)IBA 11/2008 - 04/2002
2	atezolizumabIBA 04/2022 - 01/2022
2	Immunoglobulins (Immunoglobulin)IBA 12/2020 - 10/2019
2	Interleukin-10 (Interleukin 10)IBA 10/2020 - 01/2019
2	NivolumabIBA 10/2020 - 01/2019
2	guadecitabineIBA 01/2020 - 01/2018
2	LipidsIBA 01/2020 - 02/2009
2	LigandsIBA 10/2019 - 02/2002
2	Monoclonal AntibodiesIBA 10/2019 - 12/2016
2	InterleukinsIBA 01/2019 - 11/2007
2	TOR Serine-Threonine KinasesIBA 01/2019 - 07/2014
2	Transaminases (Aminotransferases)IBA 01/2019 - 11/2011
2	danvatirsenIBA 11/2018 - 11/2015
2	Antisense OligonucleotidesIBA 11/2018 - 11/2015
2	Janus KinasesIBA 11/2018 - 11/2018
2	Docetaxel (Taxotere)FDA Link 09/2016 - 07/2014
2	lenvatinibIBA 12/2015 - 11/2015
2	sipuleucel-T (APC8015)FDA Link 01/2013 - 08/2009
2	Transforming Growth Factors (Transforming Growth Factor)IBA 03/2012 - 10/2006
2	Gemcitabine FDA Link 03/2012 - 01/2004
2	Fluorouracil (Carac)FDA LinkGeneric 02/2012 - 10/2003
2	Capecitabine (Xeloda)FDA Link 11/2011 - 01/2005
2	paclitaxel poliglumex (XYOTAX)IBA 12/2010 - 01/2005
2	talabostatIBA 07/2009 - 10/2006
2	PolymersIBA 02/2009 - 01/2005
2	advexinIBA 12/2008 - 05/2007
2	Canertinib (CI 1033)IBA 05/2007 - 05/2005
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2005 - 02/2004

Therapy/Procedure

53	Therapeutics 03/2022 - 02/2002
22	Immunotherapy 01/2022 - 02/2005
21	Drug Therapy (Chemotherapy) 10/2021 - 02/2002
5	Radiotherapy 07/2012 - 01/2003
4	Injections 01/2018 - 01/2005
3	Precision Medicine 06/2021 - 02/2017
3	Intradermal Injections 12/2016 - 03/2012
3	RNAi Therapeutics 01/2012 - 08/2010
2	Combination Drug Therapy (Combination Chemotherapy) 02/2020 - 01/2005